Research
Project
Cost-Effectiveness analysis of 3 months of weekly refapetine and isoniazid for treatment of latent tuberculosis in South Korea
January 2021 - Present
- Developed age-structured tuberculosis (TB) model
- Calibrated the model to fit yearly TB incidence data using least-squares estimation (LSE)
- Collaborated with Yunjeong Lee and Hye Seong
Cost-benefit analysis of tafenoquine for radical cure of Plasmodium vivax malaria in South Korea
October 2020 - Present
- Expanded P. vivax malaria model to decribe relapse incidences in detail
- Calibrated the model to fit weekly malaria incidence data using maximum likelihood method (MLE)
- Predicted future malaria incidences and performed cost-benefit analysis (CBA) of tafenoquine
- Conducted probabilistic sensitivity analysis (PSA)
- Collaborated with Jung Ho Kim and Joon-Sup Yeom
Development of agent-based model for malaria to predict the time for elimination in South Korea
August 2020 - Present
- Developed agent-based model (ABM) for P. vivax malaria
- Analyzed epidemiological data by region, age and sex in the malaria risk-area
- Collaborated with Chansoo Kim, Jung Ho Kim, and Joon-Sup Yeom
Analysis of differential equations with multiple delays and seasonality for malaria
April 2020 - Present
- Showed well-posedness of the multiple delay differential equations (DDEs), Cauchy problem
- Calculated basic reproduction number in the multiple DDE malaria model
- Analyzed steady states: disease-free and endemic equilibriums, Wazewski system, Sevastyanov-Kotelyanskii criterion
- Performed numerical simulations for stability analysis
- Collaborated with Hee-Dae Kwon
Evaluation of the impact of rapid diagnostic test and tafenoquine on the burden of malaria in North Korea
December 2019 - Present
- Developed P. vivax malaria model in North Korea
- Calibrated the model to fit yearly malaria incidence data using LSE
- Predicted future malaria incidences under rapid diagnostic test (RDT) and tafenoquine scenarios and performed sensitivity analysis
- Collaborated with Hye Seong and Joon-Sup Yeom
Cost-effectiveness analysis of herpes zoster vaccination in South Korea
October 2019 - Present
- Expanded varicella zoster virus (VZV) model from the previous study
- Estimate the effect of herpes zoster (HZ) vaccination on the varicella and HZ incidences
- Performed cost-effectiveness analysis based on HIRA data
- Collaborated with Sun Hee Park
Estimation of varicella vaccine effectiveness from varicella incidence data in South Korea
September 2019 - Present
- Estimated varicella vaccine effectiveness under 1-dose and 2-dose strategies
- Estimated parameters using LSE, MLE and confidence intervals using profile likelihood, bootstrapping
- Collaborated with Sun Hee Park
Cost-benefit analysis of rapid diagnostic test for malaria in South Korea
April 2019 - October 2020
- Developed P. vivax malaria model in South Korea using DDEs and incorporating seasonality
- Calibrated the model to fit weekly malaria incidence data using LSE
- Predicted future malaria incidences performed cost-benefit analysis of RDT and PSA
- Collaborated with Jung Ho Kim and Joon-sup Yeom
Estimation of the impact of 2-dose varicella vaccination on varicella and herpes zoster epidemiology in South Korea
July 2018 - December 2020
- Developed age stratified VZV model incorporating dynamic population structure
- Assessed the impact of 2-dose varicella vaccinations on the disease burden
- Estimated optimal 2nd dose timing
- Performed sensitivity analysis including WAIFW (Who Acquires Infection From Whom) matrix
- Collaborated with Sun Hee Park
Development of mixed-effects model for in-host HIV model using hierarchical Bayesian approach
May 2018 - July 2019
- Developed mixed-effects model based on the in-host HIV model
- Estimated individual and population level parameters using MCMC method
Cost-effectiveness of pre-exposure prophylaxis in men who have sex with men in South Korea
March 2017 - August 2018
- Developed population level HIV model
- Predicted HIV incidence among general and high-risk MSM
- Estimated incremental cost-effectiveness ratio (ICER) of pre-exposure prophylaxis (PrEP)
- Performed sensitivity analysis of ICER
- Collaborated with Heun Choi and Jun Yong Choi
Development of numerical algorithms for molecular diagnostic tools in Seegene
August 2015 - September 2015
- Developed numerical algorithm to determine the baseline threshold in real-time PCR
- Developed numerical algorithm to discriminate two targets in one channel in MuDTTM technology
- Collaborated with Seegene